'World-first’ cancer genes database launched by NHS

The health service said it is building a register of 120 genes known to increase the likelihood of getting cancer – the first of its kind – as part of a 10-year plan to improve the prevention and treatment of the disease.

Cancer patients and their family members could have their genes compared to the database, allowing for earlier screening and more personalised treatments.

The NHS National Inherited Cancer Predisposition Register follows the successful Lynch syndrome register, which has seen thousands of people diagnosed with Lynch syndrome identified and offered routine preventative screening, according to NHS England.

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Speaking about the database, Professor Peter Johnson, National Clinical Director for Cancer at NHS England, said it would allow thousands more people to access the latest treatments.

"We are entering a new era of cancer prevention with pioneering research and testing helping us to discover more about how genes influence our chances of developing cancer.

“Finding out you have an inherited risk of cancer can be life-changing, but it also supports people to access tailored advice on risk-reducing steps and vital monitoring, to increase the chances of any cancers being picked up early or even preventing the disease altogether.”

Those identified as having an inherited risk of cancer will be added to the register, and will be automatically invited to screening and offered routine tests.

Health Secretary Wes Streeting said the programme was part of a plan “to modernise our NHS so it is fit for the 21st century”.

“One in every two people will get cancer in their lifetime but that does not mean the chances are random – many people face a higher risk through the genes they inherit.

"And while we cannot do anything about inherited genes we can do something about what we do with that information.”

He said that launching this "world-leading genetic register" would allow the NHS to provide personalised and preventative care sooner.

“This register won’t just supercharge innovation – it will be life changing and life-saving, allowing the NHS to develop individual care, fast-track screening and tailored information to enable more cancers to be caught earlier.

”The database could be used to expedite access to earlier screening and testing, as well as personalised treatment for thousands of patients.

Patients could also be tested to determine if their genetic profile means their cancer would be more responsive to particular treatments.

Claire Rowney, chief executive of Breast Cancer Now, said the system could have the potential to “transform lives”.

“We are delighted to see the UK Government commit to creating a comprehensive national database for people at an increased risk of cancer, to facilitate better access to earlier, more frequent screening and to risk-reducing treatments,” she said.

“This is something Breast Cancer Now has been calling for, and it has the potential to transform the lives of women who are at increased risk of breast cancer due to their family history or genetics, by making sure they are offered the right support and treatment to help manage their risk.”