Mixing AstraZeneca and Pfizer Covid jabs 'generates robust immune response'

28 June 2021, 16:13 | Updated: 28 June 2021, 16:27

The study showed that Pfizer and Oxford vaccines mixed together could induce a high concentration of antibodies.
The study showed that Pfizer and Oxford vaccines mixed together could induce a high concentration of antibodies. Picture: PA

By Emma Soteriou

Mixing the Pfizer-BioNTech and Oxford-AstraZeneca vaccines generates a robust immune response against coronavirus, research has found.

The Com-COV study, run by the University of Oxford, found that using the Pfizer and AstraZeneca vaccines interchangeably resulted in high concentrations of antibodies against the virus, when given four weeks apart.

Findings also suggested that the order of vaccines made a difference, with the AstraZeneca followed by Pfizer inducing higher antibodies than if the Pfizer were given first.

That said, both schedules produced higher antibodies than the standard two-dose AstraZeneca schedule.

Professor Matthew Snape, chief investigator on the trial and associate professor in paediatrics and vaccinology at the University of Oxford, said: "The Com-COV study has evaluated 'mix and match' combinations of the Oxford and Pfizer vaccines to see to what extent these vaccines can be used interchangeably, potentially allowing flexibility in the UK and global vaccine rollout.

"The results show that when given at a four-week interval both mixed schedules induce an immune response that is above the threshold set by the standard schedule of the Oxford-AstraZeneca vaccine.

"The investigators would like to thank the participants that made this important study possible."

Read more: Third Oxford/AstraZeneca jab 'could be effective booster' to tackle Covid variants

Read more: Double-jabbed arrivals from amber countries won't have to isolate 'later in summer'

Nadhim Zahawi confirms three in five UK adults have been double-jabbed

More flexibility with vaccines could help in the rollout on a global scale, with people being able to receive any jab that is available instead of having to wait for a matching one.

However, the findings were from an interval of four weeks between each dose, which is much shorter than the eight to 12-week schedule that is currently being used.

Professor Snape said: "This longer interval is known to result in a better immune response, and the results for a 12-week interval will be available shortly."

Deputy chief medical officer, Professor Jonathan Van-Tam, explained that results from the study of the 12-week interval could make a bigger difference in decisions around the vaccine rollout.

"Today's data are a vital step forward, showing a mixed schedule gives people protective immunity against Covid-19 after four weeks," he said.

"Equally, they offer supportive evidence that the standard (non-mixed) JCVI (Joint Committee on Vaccination and Immunisation) recommendations for Covid-19 vaccination all produce highly satisfactory immune responses, for both main vaccines in use.

"Given the UK's stable supply position there is no reason to change vaccine schedules at this moment in time.

"The results for the 12-week interval, which are yet to come, will have an instrumental role to play in decisions on the future of the UK's vaccination programme.

"Our non-mixed vaccination programme has already saved tens of thousands of lives across the UK but we now know mixing doses could provide us with even greater flexibility for a booster programme, while also supporting countries who have further to go with their vaccine rollouts and who may be experiencing supply difficulties."

More Latest News

See more More Latest News

Lee Anderson has been suspended for his comments about Sadiq Khan

Lee Anderson suspended from Conservative Party after claiming 'Islamists have control of Sadiq Khan'

Wet weather is expected on Sunday and Monday

Fears of travel chaos on Sunday and Monday amid heavy rain, as yellow weather warning issued

Jesse Baird and Luke Davies have not been seen since Monday

Police in desperate riverbed hunt for missing TV presenter and boyfriend, as cop ex-lover accused of murder

Yulia Navalnaya

Navalny widow accuses Putin of mocking Christianity for refusing to return body

Volodymyr Zelensky

Western leaders arrive in Kyiv as Ukraine marks invasion anniversary

Charles has shared a message of support for Ukraine

King Charles hails 'heroism' of Ukrainians as world leaders mark second anniversary of Russian invasion in Kyiv

Junior doctors have gone on strike again

Junior doctors walk out for five-day strike amid long-standing pay row, in latest round of NHS industrial action

Sarah Oliver was killed in the collision

Woman killed by driver who sped through red light while on her phone, as she is jailed for nine years

Spain Building Fire

10th body found in charred remnants of Valencia apartment building

Luiz Inacio Lula da Silva

Brazilian president accuses Israel of committing genocide in Gaza

Hamilton Palace is said to be abandoned

Crumbling Sussex mansion abandoned by millionaire developer 'is UK's biggest slum' and is 'magnet for drug abuse'

Grant Shapps has vowed that Britain will back Ukraine 'to the end'

'We will be there to the end': Shapps vows UK will back Ukraine until war is over, as Britain gives £245m military aid

Exclusive
LBC spoke to a mother and daughter from the war-torn city of Mariupol

Ukrainian refugees accuse Home Office of becoming ‘tired of Ukraine’ after altering resettlement schemes

Rishi Sunak has been urged to strip Liz Truss of the Conservative whip

Labour urges Rishi Sunak to strip former PM Liz Truss of Conservative whip after claim of 'deep state sabotage'

Ursula von der Leyen

EC chief von der Leyen arrives in Kyiv as Ukraine marks invasion anniversary

Mel B

'I went from Spice Girls tour to sharing a bed with my kids': Mel B had just £700 in the bank after leaving abusive ex